MedTerm Speak

Master the language of medicine

Z-disc

ZEE-disk

/ˈziː dɪsk/

The boundary between sarcomeres in muscle tissue where actin filaments are anchored.

Z-DNA

ZEE-D-N-A

/ˈziː diː ɛn eɪ/

A left-handed double helical form of DNA, different from the more common right-handed B-DNA.

Z-ligament

ZEE-LIG-ah-ment

/ˈziː ˈlɪɡəmənt/

A rare synonym for the iliofemoral ligament of the hip (the Y-ligament).

Z-line

ZEE-lyn

/ˈziː laɪn/

The squamocolumnar junction where the lining of the esophagus meets the lining of the stomach.

Z-plasty

ZEE-plas-tee

/ˈziː ˈplæsti/

A surgical technique used to improve the functional and cosmetic appearance of scars by redirecting tension.

Z-track injection

ZEE-trak

/ˈziː træk ɪnˈdʒɛkʃən/

A technique for intramuscular injection that prevents medication from leaking into the subcutaneous tissue.

Zafirlukast

zah-feer-LOO-kast

/zəˈfɪərluːkæst/

An oral leukotriene receptor antagonist used for the maintenance treatment of asthma.

Zaleplon

ZAL-eh-plon

/ˈzæləplɒn/

A sedative-hypnotic medication used for the short-term treatment of insomnia.

Zeatin

ZEE-ah-tin

/ˈziːətɪn/

A plant hormone derived from adenine, sometimes studied in regenerative medicine for cell growth properties.

Zeaxanthin

zee-ah-ZAN-thin

/ˌziːəˈzænθɪn/

A carotenoid pigment found in the retina (macula) that helps protect the eye from light damage.

Zebra body

ZEE-brah BOD-ee

/ˈziːbrə ˈbɒdi/

Transverse striped lysosomal structures seen in cells under electron microscopy in certain metabolic diseases like Fabry disease.

Zein

ZEE-in

/ˈziːɪn/

A group of proteins found in maize, used in pharmaceutical manufacturing for coating pills.

Zeis gland

ZYS gland

/zaɪs ɡlænd/

Small sebaceous glands located at the free edge of the eyelids, associated with eyelash follicles.

Zeitgeber

ZAYT-gay-ber

/ˈtsaɪtˌɡeɪbər/

An external cue, such as daylight, that helps regulate the body's internal biological clock.

Zeller's test

ZEL-erz

/ˈzɛlərz/

A historical laboratory test for the presence of melanin in the urine.

Zenker's necrosis

neh-KROH-sis

/ˈzɛŋkərz nɪˈkroʊsɪs/

Severe hyaline degeneration or necrosis of skeletal muscle, historically associated with typhoid fever.

Zenker’s diverticulum

ZENG-kerz

/ˈzɛŋkərz ˌdaɪvərˈtɪkjʊləm/

A pouch that forms at the junction of the lower throat and upper esophagus, causing difficulty swallowing.

Zenker’s fluid

ZENG-kerz

/ˈzɛŋkərz/

A rapid-acting histological fixative used to preserve animal tissues for microscopic study.

Zeosis

zee-OH-sis

/ziːˈoʊsɪs/

The formation of blebs or bubbles on the surface of a cell as it undergoes apoptosis.

Zero-order kinetics

kih-NET-iks

/ˈzɪəroʊ ˈɔːrdər kɪˈnɛtɪks/

A process where the rate of drug elimination is constant regardless of its concentration (e.g., ethanol metabolism).

Zeroing

ZEER-oh-ing

/ˈzɪəroʊɪŋ/

The process of calibrating a medical monitoring device (like an arterial line) to atmospheric pressure.

Zest

ZEST

/zɛst/

In psychiatry, a measure of an individual's enthusiasm and energy levels toward life activities.

Zidovudine

zy-DOH-vyoo-deen

/zaɪˈdoʊvjʊˌdiːn/

An antiretroviral medication (AZT) used to treat HIV/AIDS.

Zidovudine (AZT)

zy-DOH-vyoo-deen

/zaɪˈdoʊvjʊˌdiːn/

The first antiretroviral drug approved for the treatment of HIV infection.

Ziehl-Neelsen stain

ZEEL NEEL-sun

/ˌziːl ˈniːlsən/

An acid-fast stain used to identify Mycobacterium tuberculosis and other acid-fast organisms.

Zinc

ZINGK

/zɪŋk/

An essential trace element necessary for immune function, wound healing, and DNA synthesis.

Zinc deficiency

ZINGK

/zɪŋk dɪˈfɪʃənsi/

A nutritional condition causing growth retardation, hair loss, and delayed wound healing.

Zinc oxide

OK-syd

/zɪŋk ˈɒksaɪd/

A white powder used in ointments to treat skin irritations and as a physical sunblock.

Zinc pyrithione

py-RITH-ee-ohn

/zɪŋk ˌpaɪrɪˈθaɪoʊn/

An antifungal and antibacterial agent commonly used in over-the-counter dandruff shampoos.

Ziprasidone

zih-PRAS-ih-dohn

/zɪˈpræsɪdoʊn/

An atypical antipsychotic used to treat schizophrenia and bipolar disorder.

Zirconium

zer-KOH-nee-um

/zərˈkoʊniəm/

A metal used in dentistry for high-strength crowns and bridges due to its biocompatibility.

Zollinger-Ellison syndrome

ZOL-in-jer EL-ih-sun

/ˈzɒlɪndʒər ˈɛlɪsən/

A condition in which tumors in the pancreas or duodenum cause the stomach to produce too much acid.

Zolmitriptan

zol-mih-TRIP-tan

/ˌzoʊlmɪˈtrɪptæn/

A medication (triptan) used for the acute treatment of migraine attacks.

Zolpidem

ZOL-pih-dem

/ˈzɒlpɪdɛm/

A sedative-hypnotic drug used for the short-term treatment of sleeping problems; brand name Ambien.

Zona

ZOH-nah

/ˈzoʊnə/

In anatomy, a region or area with distinct characteristics (e.g., Zona glomerulosa of the adrenal gland).

Zona fasciculata

fah-sik-yoo-LAH-tah

/ˈzoʊnə fəˌsɪkjʊˈlɑːtə/

The middle layer of the adrenal cortex that produces glucocorticoids like cortisol.

Zona glomerulosa

gloh-mer-yoo-LOH-sah

/ˈzoʊnə ɡləˌmɛrjʊˈloʊsə/

The outermost layer of the adrenal cortex that produces mineralocorticoids (aldosterone).

Zona pellucida

ZOH-nah peh-LOO-sih-dah

/ˈzoʊnə pəˈluːsɪdə/

The thick, transparent membrane surrounding a mammalian ovum (egg) before implantation.

Zona reticularis

reh-tik-yoo-LAIR-is

/ˈzoʊnə rəˌtɪkjʊˈlɛərɪs/

The innermost layer of the adrenal cortex that produces androgens.

Zonal

ZOH-nul

/ˈzoʊnəl/

Pertaining to a specific zone or area within an organ or tissue.

Zonula adherens

ZON-yoo-lah ad-HEER-enz

/ˈzɒnjʊlə ædˈhɪərɛnz/

A type of cell junction in epithelial tissues that helps hold cells together.

Zonula occludens

ok-LOO-denz

/ˈzɒnjʊlə əˈkluːdɛnz/

A tight junction; the area where two cell membranes are joined together to form an impermeable barrier.

Zonule of Zinn

ZON-yool of ZIN

/ˈzɒnjuːl əv zɪn/

A ring of fibrous strands connecting the ciliary body with the crystalline lens of the eye.

Zonulitis

zon-yoo-LY-tis

/ˌzɒnjʊˈlaɪtɪs/

Inflammation of the zonule of the eye.

Zonulolysis

zon-yoo-LOL-ih-sis

/ˌzɒnjʊˈlɒlɪsɪs/

The enzymatic dissolution of the zonule of the lens during cataract surgery.

Zoonosis

zoh-oh-NOH-sis

/ˌzoʊəˈnoʊsɪs/

An infectious disease that has jumped from a non-human animal to humans.

Zoonotic

zoh-oh-NOT-ik

/ˌzoʊəˈnɒtɪk/

Relating to a disease that can be transmitted from animals to humans.

Zopiclone

ZOP-ih-klohn

/ˈzɒpɪkloʊn/

A nonbenzodiazepine hypnotic used in the treatment of insomnia.

Zoster

ZOS-ter

/ˈzɒstər/

Short for Herpes Zoster; the virus that causes shingles.

Zoster sine herpete

SY-nee HER-peh-tee

/ˈzɒstər ˈsiːneɪ ˈhɜːrpɛtiː/

Pain caused by shingles without the typical visible skin rash.

Zosteroid

ZOS-ter-oyd

/ˈzɒstərɔɪd/

Resembling shingles, particularly in the distribution of skin lesions along a nerve path.

Zuckerkandl, Organ of

TSOOK-er-kahn-dul

/ˈtsʊkərˌkændəl/

A chromaffin body derived from neural crest cells located at the bifurcation of the aorta.

Zygapophysial joint

zy-gah-poh-FIZ-ee-ul

/ˌzaɪɡəpəˈfɪziəl/

The facet joint; a synovial joint between the superior and inferior articular processes of vertebrae.

Zygapophysis

zy-gah-POF-ih-sis

/ˌzaɪɡəˈpɒfɪsɪs/

The articular process of a vertebra that forms a joint with the adjacent vertebra.

Zygodactyly

zy-goh-DAK-tih-lee

/ˌzaɪɡəˈdæktɪli/

A form of syndactyly where two or more fingers or toes are fused.

Zygoma

zy-GOH-mah

/zaɪˈɡoʊmə/

The cheekbone; also known as the zygomatic bone.

Zygoma fracture

zy-GOH-mah

/zaɪˈɡoʊmə ˈfræktʃər/

A break in the cheekbone, often occurring as part of a tripod fracture in facial trauma.

Zygomatic arch

zy-goh-MAT-ik

/ˌzaɪɡəˈmætɪk ɑːrtʃ/

The bony arch formed by the cheekbone and the temporal bone.

Zygomaticofacial nerve

zy-goh-MAT-ih-koh-FAY-shul

/ˌzaɪɡəmætɪkoʊˈfeɪʃəl/

A branch of the maxillary nerve that provides sensation to the skin of the cheek.

Zygomaticotemporal nerve

TEM-por-ul

/ˌzaɪɡəmætɪkoʊˈtɛmpərəl/

A branch of the maxillary nerve that provides sensation to the skin of the temple.

Zygomaticus major

MAY-jor

/ˌzaɪɡəˈmætɪkəs ˈmeɪdʒər/

A muscle of facial expression that draws the angle of the mouth up and back (the 'smiling muscle').

Zygomaticus minor

MY-nor

/ˌzaɪɡəˈmætɪkəs ˈmaɪnər/

A muscle of facial expression that elevates the upper lip.

Zygomycosis

zy-goh-my-KOH-sis

/ˌzaɪɡəmaɪˈkoʊsɪs/

A rare but serious fungal infection caused by molds of the order Mucorales.

Zygote

ZY-goht

/ˈzaɪɡoʊt/

The cell formed by the fusion of a sperm and an egg; a fertilized ovum.

Zygote intrafallopian transfer (ZIFT)

ZY-goht

/ˈzaɪɡoʊt/

An infertility treatment where a fertilized egg is placed into the fallopian tube.

Zymase

ZY-mays

/ˈzaɪmeɪs/

An enzyme complex found in yeast that catalyzes the fermentation of sugar into alcohol.

Zymogen

ZY-moh-jen

/ˈzaɪmədʒən/

An inactive substance that is converted into an enzyme when activated by another enzyme.

Zymology

zy-MOL-oh-jee

/zaɪˈmɒlədʒi/

The study of fermentation and its medical/biochemical applications.

Zymolysis

zy-MOL-ih-sis

/zaɪˈmɒlɪsɪs/

The action of an enzyme or fermentation process.

Zymoprotein

zy-moh-PROH-teen

/ˌzaɪməˈproʊtiːn/

A protein that possesses enzymatic properties.